CD127 APC

The clone 4G8, a mouse monoclonal antibody selectively recognizes a 60-90 kDa surface type 1 transmembrane glycoprotein antigen known as CD127 or IL-7 receptor α chain (IL-7Rα). CD127 forms a heterodimer with the common γ chain of the receptors of several cytokines such as IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. It is widely expressed on different subsets of B cells, peripheral T cells and bone marrow stromal cells. CD127 plays important role in the generation of memory and effector T cells as well as functional B cells.