CD203c Unconjugated

CBI.207 is a recombinant monoclonal antibody that specifically targets CD203c. CD203c, also known as ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP3 or ENPP3), is a type II transmembrane glycoprotein belonging to the E-NPP family of ectoenzymes. It plays a role in hydrolyzing extracellular nucleotides, including nucleoside triphosphates, nucleoside diphosphates, cyclic AMP (cAMP), and nicotinamide adenine dinucleotide (NAD), thereby modulating purinergic signaling pathways. This protein is predominantly expressed on basophils and mast cells, with its expression levels significantly increasing upon activation by allergens or IgE receptor cross-linking. Such upregulation makes CD203c a valuable marker for assessing basophil activation in allergic responses. Additionally, CD203c expression has been observed in secretory glands of the endometrium and in glioma cells.