CD42b PerCP-Cyanine5.5

CBI.253 is a recombinant monoclonal antibody that specifically targets CD42b, a glycoprotein also referred to as GPIbα, which is encoded by the GP1BA gene. CD42b associates with CD42c through a disulfide linkage to generate the GPIb heterodimer (~170 kDa). This heterodimer further associates with CD42a and CD42d to form the CD42 complex, a receptor complex present on the surface of platelets and megakaryocytes. Functionally, the CD42 complex mediates platelet adhesion by serving as the binding site for von Willebrand factor (vWF) and also contributes to thrombin interaction during hemostasis.