HNO223 Cells

The HNO223 cell line is derived from an oral squamous cell carcinoma, which is a subtype of head and neck squamous cell carcinoma (HNSCC). This cell line has been cytogenetically characterized, revealing significant DNA copy number gains in several chromosomal regions, including 3q22-qter, 8q, 9p, 9q, 11q13, 20p, and 20q. These regions are of particular interest as they frequently contain oncogenes implicated in the progression of HNSCC, such as those involved in cell proliferation, survival, and metastasis. The amplification of 11q13, observed in HNO223, is associated with the overexpression of key oncogenes like CCND1 (cyclin D1) and CTTN (cortactin), which are known to contribute to the aggressive behavior of cancer cells, including enhanced cell cycle progression and increased invasiveness. This makes HNO223 a relevant model for investigating the molecular pathways involved in oral squamous cell carcinoma and for exploring therapeutic strategies targeting these genetic alterations. HNO223 serves as a robust model in cancer research, particularly for studies aiming to understand the genetic and molecular underpinnings of HNSCC and for the development of targeted therapies that address these specific chromosomal abnormalities. Its genetic characteristics make it a valuable tool for both basic and translational research in oncology.