A704 Cells

A-704 is a human epithelial cell line derived from kidney tissue of a 78-year-old male patient with adenocarcinoma. This cell line exhibits an epithelial morphology. It is a valuable resource in cancer research, particularly for studying adenocarcinoma. A-704 is a versatile cell line with applications in 3D cell culture and as a transfection host. Derived by D.J. Giard, A-704 maintains consistency and reliability in experimental settings. Karyotype analysis reveals that A-704 cells exhibit abnormalities such as breaks, dicentrics, and endoreduplication, ranging from diploid to hyperdiploid, hypertriploid to hypertetraploid. While not tumorigenic in immunosuppressed mice, A-704 cells can form colonies in a semisolid medium. A-704 cells exhibit specific isoenzyme profiles, including AK-1, ES-D, G6PD, GLO-I, Me-2, PGM1, and PGM3.