HOS Cells

The HNO97 cell line is derived from an oral squamous cell carcinoma, a subtype of head and neck squamous cell carcinoma (HNSCC). This cell line has been cytogenetically characterized, showing significant chromosomal aberrations. Specifically, HNO97 exhibits DNA copy number gains in regions including 3p25-pter, 3q, 5p, 9q22-qter, 10p, 10q, 11cen-p14, 20p, and 20q. Additionally, it shows a notable copy number loss in the 18q region. These genetic alterations are consistent with those observed in other HNSCC cases and are associated with tumor progression and poor prognosis. The genetic profile of HNO97, particularly the amplification of regions like 3q and 11cen-p14, which harbor oncogenes implicated in cancer progression, makes this cell line a valuable model for studying the molecular mechanisms underlying oral squamous cell carcinoma. The loss of 18q, a region often deleted in cancers, further emphasizes its relevance in cancer research. HNO97 is a significant resource for exploring the genetic drivers of HNSCC and for testing targeted therapeutic approaches that address these specific chromosomal changes.