MKN-45 Cells

The MKN-45 cell line is a human gastric cancer cell line, derived from the poorly differentiated adenocarcinoma of the stomach. These cells exhibit characteristics typical of gastric cancer, including rapid growth and a high degree of genetic instability. MKN-45 cells are commonly used in cancer research to study tumor biology, drug resistance mechanisms, and the molecular pathways involved in gastric cancer progression. Their ability to form tumors when xenografted into immunocompromised mice makes them a valuable model for in vivo studies. MKN-45 cells are epithelial in nature and grow as adherent cells in culture. They express various biomarkers relevant to gastric cancer, such as carcinoembryonic antigen (CEA) and E-cadherin, making them useful for diagnostic and therapeutic research. Additionally, MKN-45 cells are often utilized in the evaluation of chemotherapy drugs and targeted therapies due to their responsiveness to treatment and their ability to mimic the clinical behavior of human gastric tumors. Researchers also use this cell line to explore the effects of genetic modifications and to develop new therapeutic strategies aimed at improving patient outcomes in gastric cancer.