SW-1463 Cells

The SW-1463 cell line is derived from a human adenocarcinoma of the rectum. It is part of the extensive SW series of cancer cell lines, which have been characterized for their unique genetic and molecular profiles. SW-1463 is notable for its epithelial morphology and tumorigenic potential in immunocompromised mice. The cell line displays a stable growth pattern under standard culture conditions and has been extensively used in cancer biology and drug development studies. Genomic profiling of SW-1463 has revealed several mutations associated with oncogenesis, including alterations in the KRAS pathway. This makes the cell line a valuable tool for studying colorectal cancer and testing therapies targeting RAS/RAF/MEK/ERK signaling. Additionally, transcriptomic analyses have highlighted dysregulated expression of genes involved in cell cycle regulation and apoptosis, further emphasizing its utility in cancer research. SW-1463 has also been integrated into high-throughput drug screening programs, where it has shown diverse responses to chemotherapeutic agents and targeted therapies. These studies provide insights into the mechanisms of drug resistance and sensitivity, aiding in the development of personalized medicine strategies.