SW527 Cells

The SW527 cell line is a human breast carcinoma cell line derived from a Caucasian adult patient. It was established in the early 1970s and has been included in foundational studies characterizing tumorigenicity in immunodeficient models. In one such study, SW527 successfully formed tumors in nude mice following subcutaneous inoculation of 6 × 106 cells, supporting its malignant origin. Histopathological analysis of the resulting tumors showed features consistent with the original human carcinoma, confirming its relevance as a breast cancer model. SW527 has been authenticated as a tumor-derived line of G6PD type B, a classification that helps exclude contamination with HeLa cells, which is a critical concern in historical cell line collections. Despite this, comprehensive molecular or immunological profiling of SW527 appears limited in recent large-scale datasets. Overall, SW527 remains a validated breast carcinoma model, primarily supported by in vivo tumorigenicity data. Additional molecular profiling would be beneficial to broaden its utility in mechanistic or drug discovery research.