HK-CRISPR-mEGFP-Seh1 Cells

The HK-CRISPR-mEGFP-Seh1 cell line is engineered for precise genomic editing using the CRISPR/Cas9 system, targeting the Seh1 gene. Seh1 is part of the nuclear pore complex, crucial for nucleocytoplasmic transport. The inclusion of monomeric enhanced green fluorescent protein (mEGFP) allows for visualization of Seh1, aiding studies on its cellular localization and function. This cell line is valuable for research on Seh1's roles in cellular processes such as mitosis and gene expression. The fluorescent tagging with mEGFP enables live-cell imaging, facilitating investigations into diseases linked to nuclear pore complex dysfunction, including certain cancers and neurodegenerative disorders. The HK-CRISPR-mEGFP-Seh1 cell line combines genetic modification with advanced imaging for comprehensive biomedical research.