MARC-145 Cells

The MARC-145 cell line is a monkey kidney epithelial cell line derived from the African green monkey (Cercopithecus aethiops). This cell line is particularly notable for its use in virology, especially in the propagation of porcine reproductive and respiratory syndrome virus (PRRSV), a significant pathogen in the swine industry. MARC-145 cells have been instrumental in studying PRRSV due to their high susceptibility to the virus, making them a valuable tool for viral isolation, propagation, and vaccine development. MARC-145 cells are characterized by their epithelial morphology and robust growth in vitro, which facilitates large-scale production of PRRSV for research purposes. Additionally, they have been used to explore the mechanisms of PRRSV infection, including virus entry, replication, and host-pathogen interactions. This cell line has also been utilized in the development and testing of antiviral compounds and PRRSV vaccines, contributing significantly to efforts aimed at controlling this economically important disease in pigs.