Beta-TC-6 Cells

Beta-TC-6 cells is a cell line derived from insulinoma tissue in mice. These cells are crucial in scientific studies focused on diabetes and insulin signalling. Originating from a transgenic mouse, Beta-TC-6 cells carry a pseudogene construct comprising the SV40 early region, which the rat insulin gene promoter regulates. This genetic composition leads to insulin secretion in response to glucose levels. These cells exhibit epithelial morphology and primarily reside in the pancreas tissue. In addition to insulin production, these cells possess small amounts of glucagon and somatostatin. The adherence of Beta-TC-6 cells allows for convenient cultivation and manipulation during experiments and assays. Beta-TC-6 cells provide a valuable tool for scientific investigations in diabetes and insulin signalling. Their unique genetic composition, insulin-secreting capabilities, and adherence properties make them ideal for studying the intricate processes involved in glucose regulation and pancreatic function.