Ishikawa Cells

Disclaimer: The identity matching score for this sample is 79.3%, which falls below 80%, likely due to genetic changes caused by microsatellite instability, a known characteristic of this cell line.The Ishikawa cell line is a well-established model derived from endometrial adenocarcinoma of a human adult. These cells are widely used in gynecological cancer research, particularly for studying the biology and treatment of endometrial cancer. Ishikawa cells retain many of the functional characteristics of normal endometrial epithelial cells, including the expression of hormone receptors such as estrogen and progesterone receptors. This makes them a valuable tool for investigating the hormonal regulation of endometrial cancer growth and the effects of hormonal therapies on cancer cells. Ishikawa cells exhibit an epithelial morphology and are known for their ability to form glandular structures in culture, which is indicative of their differentiated state. They are responsive to hormonal stimuli, allowing researchers to study the molecular mechanisms of hormone action in the endometrium and the impact of endocrine disruptors. Additionally, Ishikawa cells are used in toxicological studies to assess the effects of various compounds on endometrial cell proliferation and differentiation. Their role in preclinical testing of chemotherapeutic agents and hormonal treatments further underscores their importance in the development of therapeutic strategies for endometrial cancer. Reproductive system cancer cell lines, Endometrium, Endometrial adenocarcinoma, Growth Conditions: Adherent, Biosafety level: BSL 1