MDA-MB-361 Cells

The MDA-MB-361 cell line is derived from a metastatic site of breast adenocarcinoma in a human adult. This cell line is utilized extensively in breast cancer research, particularly in studies investigating the molecular mechanisms of cancer metastasis, hormone receptor signaling, and therapeutic responses. MDA-MB-361 cells are estrogen receptor-positive (ER+) and HER2-positive, making them a valuable model for studying the interplay between these receptors in breast cancer progression and treatment. MDA-MB-361 cells exhibit an epithelial morphology and are known for their ability to form colonies in soft agar, indicative of their tumorigenic potential. They express key markers associated with breast cancer, including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu). These cells are frequently used to evaluate the efficacy of hormonal therapies, targeted treatments, and chemotherapeutic agents in preclinical studies. Additionally, MDA-MB-361 cells serve as a model to study the mechanisms of resistance to HER2-targeted therapies and to develop strategies to overcome such resistance. Their relevance in breast cancer research underscores their importance in advancing our understanding of cancer biology and improving therapeutic approaches for breast cancer patients.