MET-5A Cells

The MET-5A cell line is derived from mesothelial cells of the pleura in a human adult and is often used in research related to mesothelioma, a type of cancer affecting the mesothelial lining of the lungs, abdomen, and heart. These cells are crucial for studying the biology, pathogenesis, and treatment of mesothelioma, particularly in understanding how environmental factors such as asbestos exposure lead to the development of this cancer. MET-5A cells are also used to explore the mechanisms of cellular transformation, tumor progression, and the cellular responses to various chemotherapeutic agents. MET-5A cells exhibit a typical epithelial morphology and retain characteristics of normal mesothelial cells, including the expression of mesothelial markers such as cytokeratin and vimentin. These cells are responsive to inflammatory stimuli and can be used to study the inflammatory processes involved in mesothelioma pathogenesis. Researchers employ MET-5A cells to investigate the genetic and molecular alterations associated with mesothelioma, as well as to test the efficacy and toxicity of potential therapeutic compounds. The relevance of MET-5A cells in modeling mesothelial cell biology and their role in mesothelioma research makes them an essential tool for advancing our understanding and treatment of this aggressive cancer.