HSF (SV40) Cells

The HSF(SV40) immortalized cell line refers to cells that have been genetically modified to express the Simian Virus 40 (SV40) large T-antigen (T-Ag), which facilitates cellular immortalization. SV40 T-Ag is a potent oncoprotein that interacts with critical tumor suppressor proteins, such as p53 and retinoblastoma protein (Rb), leading to the inactivation of their tumor-suppressive functions. This interaction disrupts normal cell cycle control mechanisms, allowing cells to bypass senescence and proliferate indefinitely. Due to their immortalized nature and the critical involvement of SV40 T-Ag in their transformation, HSF(SV40) cells are widely used in cancer research, particularly in studies related to viral oncogenesis, cell cycle regulation, and therapeutic interventions targeting molecular chaperones and tumor suppressor pathways. Their use provides valuable insights into the interplay between viral oncoproteins and host cell regulatory networks, paving the way for the development of targeted cancer therapies.