CHO-CXCR7 Cells

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR7-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CXCR7 receptor at a medium-high level. This cell line was created using an innovative landing pad technology, which allows for targeted integration of the CXCR7 gene at a pre-validated genomic locus, ensuring consistent and reproducible expression. CXCR7, also known as ACKR3, is an atypical chemokine receptor involved in immune modulation and cancer biology. Unlike typical GPCRs, CXCR7 does not signal through G proteins but instead scavenges chemokines such as CXCL12 and CXCL11, and forms heterodimers with CXCR4, influencing processes like tumor progression, metastasis, and angiogenesis. CXCR7 is notably overexpressed in various cancers, including breast, lung, and prostate cancers, where it is linked to increased tumor growth, metastasis, and poorer prognosis. This makes the CHO-CXCR7-Medium-high cell line particularly valuable for oncology research, allowing for the study of CXCR7's role in cancer progression and its potential as a therapeutic target. The expression of CXCR7 in this cell line was confirmed using flow cytometry.