CHO-CCR8

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CCR8 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CCR8 receptor at a medium-high level, approximately 8,000 molecules per cell. This cell line was developed using advanced landing pad technology, ensuring precise and reproducible integration of the CCR8 gene at a specific, pre-validated genomic locus. CCR8, also known as CHEMR1 or CDw198, is a G protein-coupled receptor (GPCR) expressed on various immune cells, particularly regulatory T cells (Tregs). CCR8 plays a critical role in the immune suppression process within the tumor microenvironment, facilitating tumor cells' ability to evade immune detection. As such, targeting CCR8 has become a promising strategy in cancer immunotherapy to reduce Treg-mediated suppression and enhance anti-tumor immunity. The expression of CCR8 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population. Hamster cell lines, Ovary, Growth Conditions: Adherent/suspension, Biosafety level: BSL 1