SHH Rabbit pAb

Enables glycosaminoglycan binding activity, laminin-1 binding activity, and patched binding activity. Involved in several processes, including hematopoietic or lymphoid organ development, positive regulation of T cell activation, and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including animal organ development, limb morphogenesis, and neurogenesis. Located in several cellular components, including cell surface, extracellular space, and membrane raft. Is expressed in several structures, including alimentary system, central nervous system, genitourinary system, limb bud, and sensory organ. Used to study brachydactyly type A1 and holoprosencephaly 3. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease, holoprosencephaly (multiple), hypoplastic or aplastic tibia with polydactyly, middle cerebral artery infarction, and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule).