P2Y12 Rabbit mAb

Enables G protein-coupled ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP, regulation of microglial cell migration, and substrate-dependent cell migration, cell extension. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway, platelet activation, and positive regulation of ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma, cerebrovascular disease, peripheral artery disease, platelet-type bleeding disorder 8, and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12).