ABflo® 488 Rabbit anti-Mouse NCAM mAb

Predicted to enable LRR domain binding activity and phosphatase binding activity. Involved in commissural neuron axon guidance and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion, positive regulation of calcium-mediated signaling, and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane, growth cone, and neuronal cell body. Is expressed in several structures, including embryo mesenchyme, nervous system, sensory organ, skin, and urinary system. Human ortholog(s) of this gene implicated in bipolar disorder, middle cerebral artery infarction, and pancreatic cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1).