NLRP3 Rabbit mAb

Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of T-helper cell differentiation, positive regulation of cytokine production, and response to bacterium. Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly, activation of cysteine-type endopeptidase activity involved in apoptotic process, and defense response to virus. Located in cytoplasm and nucleus. Part of NLRP3 inflammasome complex. Is expressed in central nervous system and retina. Used to study CINCA Syndrome, familial cold autoinflammatory syndrome 1, and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome, Muckle-Wells syndrome, autosomal dominant nonsyndromic deafness 34, familial cold autoinflammatory syndrome 1, and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3).