PE Rabbit anti-Mouse CD121a/IL1R1 mAb

Enables interleukin-1 binding activity, interleukin-1 receptor activity, and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway, positive regulation of interleukin-1-mediated signaling pathway, and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in brain, dorsal aorta, liver, reproductive system, and spleen. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1).