ABflo® 647 Rabbit anti-Mouse T-bet/Tbx21 mAb

Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including T-helper 1 cell lineage commitment, negative regulation of T-helper 17 cell lineage commitment, and regulation of gene expression. Acts upstream of or within T cell differentiation and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system, colon, genitourinary system, sensory organ, and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and immunodeficiency 88. Orthologous to human TBX21 (T-box transcription factor 21). Synonyma: TBT1, Tbet, Tblym