Cleaved Gasdermin D (C Terminal) Rabbit mAb

Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium, positive regulation of interleukin-1 beta production, and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol, extracellular space, and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut, liver, lung, metanephros, and spleen. Orthologous to human GSDMD (gasdermin D).