HDAC6 Rabbit mAb

Enables several functions, including cytoskeletal protein binding activity, protein lysine deacetylase activity, and ubiquitin binding activity. Involved in several processes, including positive regulation of type 2 mitophagy, protein destabilization, and tubulin deacetylation. Acts upstream of or within several processes, including aggresome assembly, neuron projection morphogenesis, and protein modification process. Located in several cellular components, including dendrite, microtubule cytoskeleton, and perikaryon. Part of cytoplasmic ubiquitin ligase complex. Is expressed in several structures, including central nervous system, early embryo, gut gland, lung, and metanephros. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia and polycystic liver disease 1. Orthologous to human HDAC6 (histone deacetylase 6).