IRF1 Rabbit pAb

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism, regulation of T cell activation, and regulation of gene expression. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation, positive regulation of interleukin-12 production, and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including bone marrow, early conceptus, eye, genitourinary system, and gut. Human ortholog(s) of this gene implicated in asthma, immunodeficiency 117, lung cancer (multiple), smallpox, and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1).