CD105 Unconjugated

The clone SN6h, a mouse monoclonal antibody selectively binds to a ~95 kDa type I transmembrane homodimer glycoprotein known as CD105. It is also encoded by END (Endoglin) and belongs to the TGF-β type III receptor family. CD105 mostly expressed on vascular endothelial cells, placental syncytiotrophoblasts, mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. CD105 works as an important regulatory component of the TGF-β receptor system. CD105 expression is increased on activated endothelium tissues undergoing angiogenesis and also in cases of wound healing or dermal inflammation. CD105 may also be involved in the solid tumor metastasis, in regulation of cytoskeletal cellular organization as well as migration.