CD35 Unconjugated

CD35, also known as complement receptor 1 (CR1) or the C3b/C4b receptor, is a type I transmembrane glycoprotein present in four allelic forms of approximately 160, 190, 220, and 250 kDa. It is widely expressed on erythrocytes, granulocytes, monocytes, B cells, follicular dendritic cells, and subsets of T cells and natural killer cells. Acting as a receptor for complement fragments such as C3b, iC3b, C3dg, C4b, iC3, and iC4, CD35 regulates complement activation, promotes immune adherence, and facilitates phagocytosis by neutrophils and monocytes. The monoclonal antibody E11 specifically recognizes CD35 and is valuable for identifying cells that express this complement receptor.