CD123 Unconjugated

CBI.209 is a recombinant monoclonal antibody that specifically targets CD123.  CD123, also known as the interleukin-3 receptor alpha chain (IL-3Rα), is a 70 kDa transmembrane protein that binds interleukin-3 (IL-3) with low affinity on its own. When it associates with the common beta chain (CD131), the receptor complex exhibits high-affinity binding to IL-3 and initiates intracellular signaling pathways. CD123 is expressed on various hematopoietic cells, including myeloid progenitors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and certain B cell subsets.