CD196 Unconjugated

CD196, also known as CCR6, is a seven-transmembrane G protein-coupled chemokine receptor primarily expressed on immature dendritic cells, B cells, and subsets of memory and effector T cells, including IL-17–producing Th17 cells. Its main ligand is CCL20, though it can also bind β-defensins with lower affinity. CCR6 and CCL20 are enriched in secondary lymphoid tissues, particularly where follicle-associated epithelium overlies Peyer's patches and isolated lymphoid follicles, facilitating B cell recruitment. In humans, CCR6 plays a role in T cell migration to the skin and mucosal sites and is highly expressed on T cells found in both healthy and psoriatic skin. Its expression has been linked to inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease, largely through its role in directing Th17 cells to inflamed tissues.