CX-1 Cells

The CX-1 cell line is derived from a human colon adenocarcinoma, characterized by its metastatic potential, particularly to the liver when inoculated into suitable animal models such as athymic nude mice. CX-1 cells were generated by introducing HT-29 cells into athymic mice. These cells serve as a reliable model system for studying the intricacies of adenocarcinoma of the colon. The CX-1 cell line expresses elevated levels of the carbohydrate antigens sialosyl Lewis a (sialosyl Le^a) and carcinoembryonic antigen (CEA), which are associated with tumor progression, metastasis, and adhesion to vascular endothelium in various cancers, including colorectal carcinoma. The human colon carcinoma cell line CX-1 serves as a critical resource for understanding the molecular mechanisms of colorectal cancer metastasis.