Colo-94H Cells

The COLO-94H cell line is a human colorectal adenocarcinoma cell line derived from a metastatic site in an adult patient. These cells are epithelial in nature and exhibit characteristics typical of colorectal cancer, making them valuable for studies focused on cancer biology, drug development, and metastatic mechanisms. COLO-94H cells grow adherently and form a monolayer, which is typical for epithelial cells in culture. They possess a high degree of genetic and phenotypic stability, allowing for reproducible results in various experimental setups. Researchers utilize the COLO-94H cell line to investigate the molecular and cellular pathways involved in colorectal cancer progression and metastasis. This includes studying the effects of oncogenes, tumor suppressor genes, and signaling pathways such as Wnt, Notch, and PI3K/AKT. Additionally, COLO-94H cells are used to evaluate the efficacy and toxicity of new chemotherapeutic agents and targeted therapies, providing a reliable in vitro model for preclinical testing. Their metastatic origin also makes them suitable for research into the mechanisms of cancer cell dissemination and colonization of secondary sites.