C643 Cells

The cell line C643 was established from a fine-needle biopsy of an anaplastic thyroid carcinoma of a 76-year-old man by Mark et al. in 1987. The patient died within 5 months after diagnosis. Demonstration of thyroglobulin mRNA ascertained a thyroid epithelial origin of the cell line. C643 cells emerge as a valuable tool for thyroid cancer research. These cells originated from human thyroid cancer tissue and represented metastatic PTC, FTC, and ATC. Their genetic makeup reflects the common mutations observed in thyroid cancer, such as alterations in BRAF, RAS, and PI3K genes, which activate critical signalling pathways. This makes C643 cells an ideal model for investigating the mechanisms involved in thyroid cancer development and progression. Furthermore, C643 cells are a crucial resource for testing potential targeted therapies. Their inclusion in preclinical studies can aid in identifying and evaluating novel compounds that specifically target the altered signalling pathways implicated in thyroid cancer. By accurately representing human thyroid cancer, C643 cells contribute to developing more effective treatments for patients with advanced thyroid cancer.