Colo-680N Cells

COLO-680N is a human esophageal squamous cell carcinoma cell line derived from the tumor biopsy of a 58-year-old woman in 1985. This derivation was unique as it involved passage through a nude mouse, a method used to enhance tumor cell growth and adaptation in vitro by leveraging the immunodeficient nature of the mouse. This process potentially selects for more aggressive and clinically relevant cancer cells, making COLO-680N particularly valuable for studying the intricate biology of esophageal squamous cell carcinoma, a major subtype of esophageal cancer.