8305C Cells

The 8305C cell line is a human thyroid carcinoma cell line derived from an undifferentiated anaplastic carcinoma of the thyroid. These cells are characterized by their aggressive growth behavior and poor differentiation, which are hallmarks of anaplastic thyroid carcinomas. This cell line retains several key features that are relevant to the study of thyroid cancer pathophysiology, including alterations in gene expression profiles and signaling pathways that are pivotal in thyroid carcinogenesis. Studies utilizing the 8305C cell line have demonstrated its utility in exploring the molecular mechanisms underlying thyroid cancer progression, resistance to therapy, and metastasis. Specifically, this cell line has been used to investigate the efficacy of various chemotherapeutic agents and targeted therapies, making it a valuable model for preclinical drug testing. Additionally, 8305C has been employed in research focusing on the role of genetic and epigenetic modifications in thyroid cancer, offering insights into potential therapeutic targets and biomarkers for this aggressive cancer type. Due to its derivation from a high-grade malignancy, the 8305C cell line serves as an important tool in thyroid cancer research, particularly in studies aimed at understanding the aggressive behavior of anaplastic thyroid carcinoma and developing strategies for its effective treatment.