Hs-746T Cells

The Hs-746T cell line is derived from human gastric carcinoma, representing a valuable in vitro model for studying gastric cancer biology and therapeutic interventions. These cells exhibit epithelial morphology and are known for their adherent growth properties. The Hs-746T cells harbor a MET gene amplification, which is a significant feature as it contributes to the oncogenic signaling pathways involved in gastric cancer. This amplification makes the Hs-746T cell line particularly useful for research focused on targeted therapies against MET and its downstream signaling pathways. Researchers utilize the Hs-746T cell line to investigate various aspects of tumor biology, including cell proliferation, migration, invasion, and response to chemotherapeutic agents. The genetic and phenotypic characteristics of Hs-746T cells make them an essential tool for studying the molecular mechanisms underlying gastric carcinoma and for the development and testing of new anti-cancer drugs. The availability of this cell line has facilitated numerous studies aimed at understanding the role of MET amplification in cancer progression and treatment resistance, thereby contributing to the advancement of precision medicine in oncology.