HAL-01 Cells

The HAL-01 cell line is derived from the peripheral blood of a female adolescent with a diagnosis of acute lymphoblastic leukemia (ALL), specifically the L2 subtype. This cell line is particularly notable for containing the t(17;19)(q22;p13) chromosomal translocation, which results in the TCF3-HLF (E2A-HLF) fusion gene. This genetic feature is critical in the study of leukemia as it influences the behavior of leukemia cells, including aspects of their growth, differentiation, and response to therapies. The presence of the TCF3-HLF fusion gene in the HAL-01 cell line makes it an invaluable resource for oncological research, particularly for studies focused on the mechanisms of leukemogenesis and the development of targeted therapies for leukemia. The fusion protein encoded by this gene is involved in the regulation of gene transcription and has been associated with poor prognosis in patients, underscoring the importance of this cell line in therapeutic development and prognostic research in acute lymphoblastic leukemia.