CHO-CXCR4 Cells

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR4-Low cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line that expresses the CXCR4 receptor at a low level, approximately 400 molecules per cell. This cell line was developed using an innovative landing pad technology, which allows for targeted integration of the CXCR4 gene at a pre-validated genomic locus. This approach ensures consistent and reproducible expression of the CXCR4 receptor across cell populations. CXCR4, also known as CD184, is a chemokine receptor that is significant in immune cell trafficking, hematopoiesis, and as a co-receptor for HIV entry into cells. It plays a key role in the migration and homing of hematopoietic stem cells and leukocytes through its interaction with the ligand CXCL12. In oncology, CXCR4 is implicated in various aspects of tumor biology, including growth, metastasis, and angiogenesis. It is often overexpressed in hematological malignancies, where it is associated with therapy resistance and poor prognosis. The expression of CXCR7 in this cell line was confirmed using flow cytometry.