CHO-CXCR4 Cells

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR4-Medium-high cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line expressing the CXCR4 receptor at a medium-high level, approximately 9500 molecules per cell. This cell line was developed using an innovative landing pad technology, which ensures targeted integration of the CXCR4 gene at a pre-validated genomic locus. This approach results in consistent and reliable expression of the CXCR4 receptor, facilitating reproducible experimental outcomes. CXCR4, also known as CD184, is a chemokine receptor involved in critical biological processes such as immune cell trafficking, hematopoiesis, and as a co-receptor for HIV entry into cells. The receptor's interaction with its ligand, CXCL12, is essential for the migration and homing of hematopoietic stem cells and leukocytes. In oncology, CXCR4 plays a significant role in tumor growth, metastasis, and angiogenesis, with its expression often upregulated in various cancers, including hematological malignancies. This upregulation is frequently associated with therapy resistance and poor prognosis. The expression of CXCR7 in this cell line was confirmed using flow cytometry.