CHO-CXCR7 Cells

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-CXCR7-Low cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line expressing the CXCR7 receptor at a low level. This cell line was generated using an innovative landing pad technology, allowing for reproducible and precise integration of the CXCR7 gene at a validated genomic locus. CXCR7, also known as ACKR3, is an atypical chemokine receptor involved in various biological processes, including immune modulation and tumor biology. Unlike classical GPCRs, CXCR7 does not signal through G proteins but instead modulates cellular responses by scavenging chemokines, such as CXCL12 and CXCL11, and interacting with CXCR4 through heterodimer formation. Overexpression of CXCR7 has been implicated in several cancers, including breast, lung, and prostate, where it is associated with enhanced tumor progression, metastasis, and poor prognosis. CXCR7 contributes to cancer progression by altering the tumor microenvironment, promoting angiogenesis, and facilitating cancer cell migration and invasion. Due to its significant role in cancer biology, CXCR7 is an important target in oncology research. The expression of CXCR7 in this cell line was confirmed using flow cytometry.