HEK293-HER2 Cells

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The HEK293-HER2 cell line is a stable recombinant HEK293 cell line engineered to express the HER2 receptor at a high level, approximately 75,000 molecules per cell. This cell line was developed using inscreenex's landing pad technology, ensuring precise and reproducible integration of the HER2 gene at a specific, pre-validated genomic locus. HER2, also known as ERBB2 or CD340, is a receptor tyrosine kinase that belongs to the epidermal growth factor receptor (EGFR) family. HER2 plays a crucial role in cell growth and differentiation, often forming heterodimers with other EGFR family members, such as EGFR, HER3, or HER4, to drive cell proliferation. Overexpression of HER2 is strongly associated with certain cancers, particularly breast and ovarian cancers, making it a critical target for cancer therapies, including monoclonal antibodies like Trastuzumab (Herceptin) and Pertuzumab (Perjeta).The expression of HER2 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.