SN12C Cells

The SN12C cell line is a human renal cell carcinoma (RCC) model derived from a primary tumor of a 43-year-old male patient. This cell line has been widely used in cancer research, particularly for investigating the biology and therapeutic targeting of RCC. SN12C cells are adherent in culture and exhibit properties consistent with epithelial morphology. The cell line is also part of the NCI-60 panel, making it extensively characterized in terms of its genomic, transcriptomic, and proteomic profiles. SN12C cells have been employed in studies exploring tumor progression and metastasis. When implanted orthotopically in the renal subcapsule of nude mice, SN12C cells form primary tumors and have been shown to produce lung metastases. These metastases have been used to derive variant cell lines with enhanced metastatic potential, making SN12C a valuable model for studying the genetic and phenotypic factors driving metastasis. The cell line has also been analyzed for mutations in key oncogenes and tumor suppressors, revealing its distinct genetic alterations, including potential oncogenic drivers of RCC. SN12C has been utilized to evaluate responses to chemotherapy and targeted therapies, contributing to the understanding of RCC's drug resistance mechanisms. Its inclusion in the NCI-60 panel has enabled high-throughput drug screening and molecular profiling, aiding the identification of compounds with selective activity against RCC. These attributes make SN12C an indispensable tool for advancing both basic and translational RCC research.