Colon-26 Cells

The Colon-26 cell line, derived from a murine adenocarcinoma, was established following the induction of colon carcinoma in a BALB/c female mouse using N-Nitroso-N-methylurethane (NMU). This particular carcinogen was administered rectally, a method that efficiently models the initiation of colorectal cancer. The establishment of the Colon-26 cell line was first reported by Corbett et al. in 1975, marking a significant development in the study of carcinogen-induced cancers in animal models. Colon-26 cells are transplantable and maintain the adenocarcinoma characteristics of the original tumor, making them a valuable tool for oncological research, especially in studies related to colorectal cancer. The cell line is particularly useful for examining the efficacy of anti-cancer therapies and the molecular pathways involved in colorectal cancer progression. Due to its origin in BALB/c mice, the Colon-26 cell line is also frequently used in immunologically relevant research, providing insights into the interaction between cancer growth and the immune response in a syngeneic host.