NCI-H196 Cells

NCI-H196 Cells
NCI-H196 Cells
NCI-H196 is a small-cell lung cancer (SCLC) cell line used to study the mechanisms of cancer progres...
17 303,00Kč
Cena bez DPH: 14 300,00Kč
  • Výrobce: Cytion
  • Kód výrobce: CYT-300390

Dostupné možnosti

NCI-H196 is a small-cell lung cancer (SCLC) cell line used to study the mechanisms of cancer progression, chemotherapy resistance, and cellular responses to oxidative stress. Research involving NCI-H196 has demonstrated its sensitivity to the cytotoxic effects of pyrrolidine dithiocarbamate (PDTC), a pro-oxidant agent. PDTC induces S-phase cell cycle arrest and significantly reduces the viability of NCI-H196 cells in a dose-dependent manner. This cytotoxicity is attributed to the induction of oxidative stress, as evidenced by increased reactive oxygen species (ROS) and changes in the expression of oxidative stress-related genes. The addition of antioxidants like N-acetyl-L-cysteine (NAC) can effectively reverse PDTC-induced cytotoxicity, confirming the role of oxidative stress in cell death. Further studies have shown that PDTC enhances the cytotoxicity of cisplatin, a first-line chemotherapy drug used for SCLC treatment. Combining low doses of cisplatin with non-toxic concentrations of PDTC leads to synergistic cytotoxicity in NCI-H196 cells. This combination therapy is believed to be effective due to PDTC?s downregulation of ATP7A, a copper efflux transporter associated with cisplatin resistance. By inhibiting ATP7A, PDTC may increase intracellular copper and sensitize NCI-H196 cells to cisplatin, highlighting its potential as an adjunct therapy for SCLC. Lung cancer cell lines, Lung, Lung small cell carcinoma, Growth Conditions: Adherent, Biosafety level: BSL 1
Technické specifikace
Doprava a skladování Adherent
Poznámka k dopravě Dopravné k objednávce je závislé na BLS třídě dodávaných produktů a na konkrétních podmínkách přepravy. Před objednáním nás prosím kontaktujte a naši pracovníci Vám vždy cenu dopravy vyčíslí pro každý jednotlivý případ. Každá viála obsahuje celkem přibližně 3 miliony adherentních buněk nebo 5 milionů suspenzních buněk s typickou životaschopností po rozmrazení v rozmezí 80-95 %. Tyto údaje slouží jako obecné vodítko; ačkoli dodržujeme přísné normy kvality, přesné počty buněk a životaschopnost se mohou lot-to-lot lišit a nejsou zaručeny.
Vlastnosti
Aplikace 3D cell culture, Cancer research
Původ Human
Specifita Lung cancer cell lines
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