15P-1 Cells

15p-1 cells are a mammalian cell line derived from Mus musculus, specifically utilized for the study of cellular responses to steroid hormones. Originating from the testicular tissue of mice, these cells exhibit a unique sensitivity to androgens, which makes them particularly valuable in endocrinology and cancer research. The 15p-1 cell line expresses the androgen receptor (AR), enabling the study of androgenic effects on gene expression, cell growth, and differentiation processes. Characteristically, 15p-1 cells are used to explore the molecular pathways influenced by androgens and their role in diseases such as prostate cancer. They provide a controlled in vitro environment to dissect the interactions between androgens and their cellular receptors, facilitating insights into both normal physiological and pathological states. This cell line is also instrumental in screening potential pharmaceuticals targeting androgen-related pathways, contributing to the development of therapeutic strategies. Maintained under standard cell culture conditions, 15p-1 cells require a medium enriched with fetal bovine serum (FBS) and an optimal temperature of 37°C, along with a CO2 concentration of 5% to mimic physiological conditions. Rigorous quality control is essential to preserve their genetic and phenotypic characteristics, ensuring reliable and reproducible results in research applications.