Capan-2 Cells

The Capan-2 cell line is a human pancreatic adenocarcinoma cell line first isolated from the pancreatic tumor tissue of a 56-year-old Caucasian male. It was derived from the metastatic site in the liver, indicating its origin from a secondary tumor which makes it particularly valuable for research on metastatic processes and pancreatic cancer biology. The cells exhibit epithelial morphology and have been utilized extensively to study pancreatic cancer, drug resistance, and tumor biology. Capan-2 cells are known to express a mutated form of the Kirsten rat sarcoma viral oncogene homolog (KRAS), a common mutation in pancreatic cancer, making them a robust model for studying KRAS-driven tumorigenesis. Additionally, they are characterized by the expression of tumor suppressor gene p53 mutations and have been observed to exhibit chromosomal instabilities, which are critical features relevant to cancer progression and treatment response. This cell line has been used in numerous studies, including those evaluating chemotherapeutic efficacy, exploring molecular pathways of cancer progression, and developing targeted therapy strategies.