C8-D1A Cells

The C8-D1A cell line is an astrocyte cell line derived from the cerebral cortex of an 8-day-old C57BL/6 mouse. This cell line is extensively used in neurobiological research due to its robust astrocytic properties, which make it a representative model for studying various aspects of astrocyte function and neuron-glia interactions. The C8-D1A cells express glial fibrillary acidic protein (GFAP), a hallmark intermediate filament protein of mature astrocytes, indicating their differentiated state and astrocytic lineage. Research utilizing the C8-D1A cell line has contributed significantly to understanding neuroinflammatory responses, glial scar formation, and the role of astrocytes in neurotransmitter regulation and synaptic maintenance. These cells provide a consistent and controlled in vitro environment for dissecting molecular pathways involved in neurodegeneration, CNS injuries, and astrocyte-mediated neuroprotection. Their utility in assays related to drug discovery, particularly for neurological disorders, underscores their importance in therapeutic development processes.