OKT11 Cells

The OKT 11 monoclonal antibody is produced by a hybridoma formed through the fusion of spleen cells from immunized mice and mouse myeloma cells (P3X63Ag8U1). Specifically, the spleen cells were taken from mice immunized with leukemic cells from a patient with T-cell acute lymphoblastic leukemia (T-ALL). This hybridoma, designated as OKT 11. The OKT 11 antibody selectively binds to an antigen found on nearly all normal human peripheral T cells and approximately 95% of normal human thymocytes but does not react with B cells or null cells. It plays a crucial role in diagnosing and treating diseases related to T cell abnormalities, such as autoimmune disorders and certain leukemias.