MS751 Cells

MS751 is a tumorigenic human cervical carcinoma cell line isolated from the uterus of a female patient with epidermoid carcinoma. The cells were originally obtained from a metastatic lymph node, and they form poorly differentiated epidermoid carcinoma (grade III) when xenografted into nude mice. The tumorigenic and metastatic nature of MS751 cells makes them a valuable model for studying the processes involved in cervical cancer metastasis and tumor progression. These cells are particularly useful for investigating epithelial-to-mesenchymal transition (EMT), invasion, and metastasis, especially in relation to poorly differentiated carcinoma. One of the key molecular features of MS751 is the presence of human papillomavirus (HPV) sequences. Originally reported to contain HPV-18, more recent studies have demonstrated that MS751 cells contain partial sequences of HPV-45, particularly from the E6/E7 region, which are expressed as poly(A)+ RNA. The E6 and E7 oncoproteins are well-known for their roles in disrupting the tumor suppressor functions of p53 and Rb, respectively, which promote uncontrolled cell division and contribute to oncogenesis. The presence of these viral sequences makes MS751 highly relevant for studies on HPV-associated cervical cancers, and specifically for investigating how HPV-45 contributes to the malignancy of cervical cells. MS751 cells exhibit epithelial morphology, which is characteristic of many cervical cancer cell lines. They are widely used for research into the molecular mechanisms underlying HPV-mediated carcinogenesis, as well as for drug discovery and therapeutic screening. Given their metastatic origin and the presence of HPV sequences, MS751 provides an essential model for studying the progression of cervical cancer and testing therapeutic strategies aimed at targeting both viral and tumor-related pathways.